P123
نویسندگان
چکیده
منابع مشابه
Enhanced brain delivery of lamotrigine with Pluronic® P123-based nanocarrier
BACKGROUND P-glycoprotein (P-gp) mediated drug efflux across the blood-brain barrier (BBB) is an important mechanism underlying poor brain penetration of certain antiepileptic drugs (AEDs). Nanomaterials, as drug carriers, can overcome P-gp activity and improve the targeted delivery of AEDs. However, their applications in the delivery of AEDs have not been adequately investigated. The objective...
متن کامل13-P123 Regulation of BMP signaling pathway in Drosophila melanogaster
Meso-diencephalic dopaminergic neurons (mdDA) are involved in voluntary movements and emotion-related behavior, and selective degeneration of these neurons in the substantia nigra (Snc) causes various neurological disorders, like Parkinson’s disease (PD). Characterization of the genetic cascade(s) involved in generation and maintenance of mdDA neurons, may help in the engineering of these neuro...
متن کاملMicellization Thermodynamics of Pluronic P123 (EO20PO70EO20) Amphiphilic Block Copolymer in Aqueous Ethylammonium Nitrate (EAN) Solutions
Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) block copolymers (commercially available as Pluronics or Poloxamers) can self-assemble into various nanostructures in water and its mixtures with polar organic solvents. Ethylammonium nitrate (EAN) is a well-known protic ionic liquid that is expected to affect amphiphile self-assembly due to its ionic nature and hydro...
متن کاملDocetaxel-Loaded Pluronic P123 Polymeric Micelles: in Vitro and in Vivo Evaluation
In this work, novel docetaxel (DTX) -loaded Tween 80-free Pluronic P123 (P123) micelles with improved therapeutic effect were developed. The freeze-dried DTX-loaded P123 micelles (DTX-micelles) were analyzed by HPLC, TEM and DLS to determine the DTX loading, micelle morphology, size, respectively. The in vitro cytotoxic activity of DTX-micelles in HepG2, A549 and malignant melanoma B16 cells we...
متن کاملEffect of room temperature ionic liquids on femtosecond solvation dynamics in a triblock copolymer (P123) gel
Effect of two room temperature ionic liquids (RTIL, [pmim][Br] and [pmim][BF4]) on the solvation dynamics and anisotropy decay of coumarin 480 (C480) in P123 gel has been studied using femtosecond up-conversion. In P123 gel, C480 displays a significant excitation wavelength dependence of emission maximum (red edge excitation shift, REES of 18 nm) and solvation dynamics, which suggest heterogene...
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ژورنال
عنوان ژورنال: European Journal of Cancer Supplements
سال: 2015
ISSN: 1359-6349
DOI: 10.1016/j.ejcsup.2015.08.064